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Berberine

Berberine is a compound found in several plants, including barberry, goldenseal and phellodendron. It is sold as a dietary supplement.

Checked November 14, 2026 · General information, not medical advice

Close-up of orange and red barberry fruit on a branch — A barberry shrub. Berberine is a compound found in barberry and some other plants. Photo: Susanne Nilsson, Wikimedia Commons, CC BY-SA 2.0

What the NIH says about the evidence

NCCIH reports weak evidence that berberine might help with blood sugar control in people with type 2 diabetes. The studies differ a lot and some are poor quality, so no clear conclusion can be drawn.
On weight, NCCIH says there is not enough rigorous evidence to know whether berberine works.
Berberine is not a replacement for any medicine your doctor has prescribed.

Safety

The most common side effects are stomach pain, constipation, diarrhea and nausea.
Berberine can interact with medicines. If you take any medicine, talk with your doctor before using it.
It should not be used during pregnancy or breastfeeding, and should never be given to infants.

Please note: this page is general information, not medical advice. Ask your doctor what is right for you, especially if you have a health condition or take medicine.

Sources

Checked November 14, 2026.

Other ingredients

Seven questions to ask before you take a supplement

Products on this site that list berberine

The seller lists this ingredient. Being listed here does not mean the product works. Amounts are on the seller’s label.

Blood sugar supportAd · We get paid if you buy
Berberine
Blood sugar support supplement, capsules
Capsules with Berberine and Milk Thistle. 90-day money-back. As stated by the seller.
- 90 days money-back (seller policy)
- US only
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